An improvement in pulmonary capillary wedge pressure (in favour of furosemide) was noted in two studies. Transplant Hepatologist, University of North Carolina, Diuretics begin with 100 spiro and 40 furosemide, Starting with both drugs appears to be the preferred approach in achieving rapid natriuresis and maintaining normokalemia., Patients with the first episode of grade 2 ascites should receive an aldosterone antagonistalone, increasing stepwiseif there is no response. Which is better for congestive heart failure furosemide or metolazone? Med Clin (Barc). Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. This content does not have an Arabic version. Before using Lasix, tell your doctor if you have kidney disease, enlarged prostate, urination problems, cirrhosis or other liver disease, an electrolyte imbalance, high cholesterol, gout, lupus, diabetes, or an allergy to sulfa drugs. Mann JFE. Hypertensive crisis: What are the symptoms? You may need to use blood pressure medicine for the rest of your life. C) Give the patient an antacid with the drugs. Take control of what you put in your body. High doses of furosemide may cause irreversible hearing loss. [Continuous infusion versus bolus injection of loop diuretics in acute heart failure: a literature review]. government site. They are used to remove excess fluid and edema from the patient. Dont rely on your clients to know how and when to give their dog furosemide. It will not fix respiratory insufficiency caused by fluid overload. Please enable it to take advantage of the complete set of features! Jentzer JC, DeWald TA, Hernandez AF. Sometimes it is not safe to use certain medications at the same time. 2022 Mar 1;3(5):954-967. doi: 10.34067/KID.0006372021. analbuminemic rats compared to normal rats when furosemide was given alone, suggesting diffusion of furosemide into various tissues. Types of blood pressure medications. Keywords provided by Brent Reed, University of Maryland, Baltimore: Drug: Metolazone 60 minutes prior to furosemide, Drug: Metolazone concurrently with furosemide. Drugs.com. Because Lasix works by removing salt from the bloodstream, it can sometimes result in a loss of too much salt, which can be serious in severe cases. Unloading therapy by intravenous diuretic in chronic heart failure: a double-edged weapon? LASIX (furosemide) is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Low-phosphorus diet: Helpful for kidney disease? "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. De Vecchis R, Ciccarelli A, Pucciarelli A. J Cardiovasc Med (Hagerstown). Available for Android and iOS devices. Read our, ClinicalTrials.gov Identifier: NCT03746002, Interventional However, it is rarely given as an injection into the muscle. L-arginine: Does it lower blood pressure? A diuretic helps reduce the amount of excess fluid in the body by increasing the . 1986 Nov;22(11):787-90. Diuretic Treatment in Heart Failure. Common medications that may interact with Lasix include: People taking oral medications for diabetes may need to talk to their doctor about adjusting the dose of their medicine. Can whole-grain foods lower blood pressure? If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. 2. In patients who do not respond to aldosterone antagonists,or in patients who develop hyperkalemia, furosemide should be added., Patients with recurrent ascites should be treated with a combination of an aldosterone antagonist plus furosemide, Aldosterone antagonists are more effective than loop diuretics in the management of ascites and are the diuretics of choice.. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Circulation. About furosemide Who can and cannot take it How and when to take it Side effects Pregnancy, breastfeeding and fertility If the body is holding too much fluid, it can increase stress on the heart, cause fluid to build up in the lungs, and can also cause swelling, typically in the legs and feet. Overload can cause respiratory difficulty, so Lasix is the quicker fix for that. Brater DC, et al. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Khan TM, Patel R, Siddiqui AH. 2023 Jan 10;13(1):140. doi: 10.3390/jpm13010140. For maintenance diuretic therapy, it is recommended that spironolactone (K - sparing) be used in conjunction with chlorothiazide 4. What is kidney disease? Prophylactic administration of loop diuretics (furosemide, bumetanide, ethacrynic acid, or torsemide) is common practice, especially among people who are at risk for circulatory overload, pulmonary oedema or both. Lasix may be used with antihypertensive drugs to control high blood pressure (hypertension). kidneys may not work as well after surgery, Intermittent furosemide administration in patients with or at risk for acute kidney injury: Meta-analysis of randomized trials. Choice of drug therapy in primary (essential) hypertension. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lasix only for the indication prescribed. A few renal mechanisms are particularly important here. Ok, so why choose one type of diuretic over another? Blood pressure readings: Why higher at home? Lasix's effect is very strong. Aldactone is a type of drug called a diuretic (water pill). According to Mayo Clinic, side effects of diuretics include: Increased urination. Each type of diuretic affects a different part of your kidneys. Drug record: Diuretics. Lasix (furosemide) contains furosemide, which belongs to the loop diuretic (water pill) drug class. If congestive heart failure occurs, or large amounts of fluid are being retained, the lungs can also be affected. Lasix (furosemide) [Package Insert]. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. include protected health information. In 2003, Santos et al. Hypertension. Buy Lasix/Furosemide 20/40/100mg Trackable Delivery Buying Lasix online right now. 5) Dont prescribe furosemide and then tell the owner to give a particular dose two to three times daily as needed. FYI: The groups were stratified into degree of ascites at baseline (<4L or >4L). Although potentially able to induce diuresis in patients otherwise resistant to high doses of loop diuretics, this strategy has not been subjected to large-scale clinical trials to establish safety and clinical efficacy. If you do not have a dose-measuring device, ask your pharmacist for one. Management of Hyponatremia in Heart Failure: Practical Considerations. Careers. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This medicine is a diuretic, which helps remove extra fluid buildup in the body. The effect of a loop diuretic is at the loop of Henle, which is proximal to where aldosterone works. (Clinical Trial), Prospective, randomized, open-label, active control pilot study, Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing With Furosemide: a Pilot Study, Active Comparator: Metolazone Concurrent Dosing, 18 Years to 89 Years (Adult, Older Adult), Baltimore, Maryland, United States, 21201, Brent Reed, Associate Professor, Pharmacy Practice and Science, University of Maryland, Baltimore. Accessibility Decreased renal excretion of calcium occurs with use of chlorothiazide - preferred diuretic if nephrocalcinosis present 5. If we combine this information with your protected 2010 Nov 2;56(19):1527-34. doi: 10.1016/j.jacc.2010.06.034. Late-night eating: OK if you have diabetes? If you are taking furosemide, your doctor may need to monitor your potassium levels or have you consume more . We provide considerations about prudent use of this therapy and . Furosemide is also used alone or together with other medicines to treat high blood pressure (hypertension). The sodium helps remove water from your blood, decreasing the amount of fluid flowing through your veins and arteries. Edema due to heart failure, hepatic impairment, or renal disease. 2018;71:e13. How do I automatically upload files to my server. orodoc V, Asaftei A, Puha G, Ceasovschih A, Lionte C, Srbu O, Bologa C, Haliga RE, Constantin M, Coman AE, Petri OR, Stoica A, orodoc L. J Pers Med. Tetanus shots: Is it risky to receive 'extra' boosters? This medication can worsen gout or trigger a flare of gout. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Metolazone 5 mg by mouth administered at the same time as furosemide background therapy (120 - 160 mg intravenous bolus, followed by furosemide 120 - 160 mg intravenous bolus 12 - 24 hours after), Total measured urine output in milliliters produced after metolazone dose is given, Change in total body weight from baseline value measured prior to metolazone dose to value collected after metolazone dose, Change in serum creatinine from baseline value collected prior to metolazone dose to value collected after metolazone dose, Portion of patients with increase in serum creatinine by 0.3 mg/dL or 50% from baseline, Proportion of patients with potassium level less than 4.0 mEq/L measured after metolazone dose is given, Proportion of patients with magnesium level less than 2.0 mg/dL measured after metolazone dose is given, Proportion of patients with serum sodium level less than 135 mg/dL measured after metolazone dose is given. Lasix is the brand name for the drug Furosemide, which is a prescription based diuretic drug. Diuretics are used to decrease blood pressure and to decrease symptoms of fluid overload such as edema. We included four studies that involved 100 participants. None of the included studies assessed the clinically important outcomes noted in our protocol. sharing sensitive information, make sure youre on a federal Medically reviewed by Sophia Entringer, PharmD. Lasix is a brand name for furosemide. health information, we will treat all of that information as protected health Consistent dosing is important for management of heart failure and the comfort of the patient. How to tell if a loved one is abusing opioids. Blood transfusions are often complicated by water retention, which may worsen lung function, heart function and/or kidney function. Last updated on March 1, 2023. Effectiveness persists in impaired renal function. Lasix ( furosemide) is a potent diuretic (water pill) used to eliminate water and salt from the body used to treat excess accumulation of fluid or swelling of the body ( edema) caused by cirrhosis, chronic kidney failure, heart failure, and nephrotic syndrome. other information we have about you. Lets start by looking at the current recommendations. Then the IV albumin. information submitted for this request. Lasix non-responders: 90% responded when switched to spironolactone (response began within 2-3 days). MeSH Infographic: Transplant for Polycystic Kidney Disease. It's called diuretic-induced edema, which happens when your kidneys start retaining more sodium and water than they need and your body starts to swell, says Anegawakind of the opposite of what . Hypertension. DOI: 10.1002/14651858.CD010138.pub2, Copyright 2023 The Cochrane Collaboration. Nausea. The goal of our review was to determine whether pre-medicating blood transfusion recipients with loop diuretics prevents complications of blood transfusion. Individual Participant Data (IPD) Sharing Statement: Studies a U.S. FDA-regulated Drug Product: Studies a U.S. FDA-regulated Device Product: Product Manufactured in and Exported from the U.S.: 24-Hour Urine Output [TimeFrame:24 hours], Change in Total Body Weight [TimeFrame:Baseline and at 12 to 23 hours after metolazone dose], Change in Serum Creatinine [TimeFrame:Baseline and at 12 to 23 hours after metolazone dose], Acute Kidney Injury [TimeFrame:Baseline and at 12 to 23 hours after metolazone dose], Hypokalemia [TimeFrame:Baseline and at 12 to 23 hours after metolazone dose], Hypomagnesemia [TimeFrame:Baseline and at 12 to 23 hours after metolazone dose], Hyponatremia [TimeFrame:Baseline and at 12 to 23 hours after metolazone dose], Admission within 48 hours for acute decompensated heart failure with at least one symptom and one sign of volume overload, Receipt of loop diuretic prior to admission, Plan to administer furosemide 120 - 160 mg IV bolus twice daily over the next 24 hours with additional diuresis deemed necessary, If patient is concurrently administered intravenous vasodilator or inotrope, the dose of vasodilator or inotrope must be stable for 6 hours prior to enrollment with a plan to continue the same dose for the 24 hour duration of this study, Receipt of continuous intravenous infusion of furosemide. [Note that other, contributing mechanisms exist (including chronic systemic inflammation) but will not be expounded upon here.]. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. is used to reduce the swelling and fluid retention caused by various medical problems View Cart| Checkout Order list My Account Checkout Login MRI: Is gadolinium safe for people with kidney problems? Changes in urine volume (UV . https://www.heart.org/en/health-topics/high-blood-pressure/changes-you-can-make-to-manage-high-blood-pressure/types-of-blood-pressure-medications. This significantly increases urination. Do not take extra medicine to make up the missed dose. Just like your hair and skin color, the color of your iris is genetic. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03746002. Metolazone is used to treat fluid retention (edema) and swelling that is caused by congestive heart failure, kidney disease, or other medical conditions . 2018 Feb 1;378(5):492. : CD010138. to ensure the safety of the patient, what action do you take before and after administering the drug FOIA Would you like email updates of new search results? Generic name: furosemide [fur-OH-se-mide] An important and challenging subset of heart failure patients exhibit fluid overload despite significant doses of loop diuretics. Find out how furosemide treats high blood pressure, heart failure and oedema, and how to take it. Buy Lasix Online (Furosemide) 20mg/40mg Cheap The store will not work correctly in the case when cookies are disabled. Version: 15.01. amlodipine, lisinopril, metoprolol, losartan, furosemide, carvedilol, hydrochlorothiazide, spironolactone, chlorthalidone, torsemide. B) Make sure that the drugs are given at least 2 hours apart. Ok, enter the new millennium. Taking Lasix can cause a decrease in blood pressure as fluid is removed from the body. Side effects include increased urination and sodium loss. Talk with your doctor and family members or friends about deciding to join a study. eCollection 2022 May 26. Cochrane Database of Systematic Reviews 2015, Issue 2. The same is true after experiencing kidney failure, or even after a kidney transplant. If 40mg didn't work, another 40 wont either. Headache. Pregnant women who take Lasix are known to have higher birth weight babies than they would otherwise. 2018;138:e595. Medically reviewed by Carmen Fookes, BPharm. I hate maintenance or mindless fluids. J Am Coll Cardiol. 2012 Apr;13(4):263-72. doi: 10.1714/1056.11558. more monitoring needed), Angeli et al. 1 The incidence of heart failure in patients older than 80 years is 9 percent. What they do: They help your kidneys clear salt and water out of your body, but don't let you lose too much potassium in the process. Wrist blood pressure monitors: Are they accurate? May be used in addition to other medicines for the treatment of high blood pressure. This content does not have an English version. If this extra fluid begins to build in the lungs, a serious condition called pulmonary edema may result, which can make it difficult to provide the body with enough oxygen. Other drugs may interact with furosemide, including prescription and over-the-counter medicines, vitamins, and herbal products. Once a reasonable amount of fluid has been given, or if they are getting overloaded/at risk for overload, or they are not responding to initial fluids, just start pressors. Do not take more than your recommended dose. You should avoid becoming dehydrated while taking Lasix, but you do not need to drink a lot of extra water unless your healthcare provider recommends it. Copyright 1996-2023 Cerner Multum, Inc. Lasix changes the electrolyte balance in the bodyparticularly salt and potassium. What is the difference between metolazone and Lasix? Read More Created for people with ongoing healthcare needs but benefits everyone. Diabetes and depression: Coping with the two conditions, Diabetes and exercise: When to monitor your blood sugar. Before taking furosemide, tell your doctor if you also use metOLazone. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This medication affects the composition of the urine and can lead to changes in the levels of electrolytes, including potassium. Read our, Bumex vs. Lasix: Compare Hypertension Treatment, Causes of Acute Renal Failure and Their Treatments. For these individuals, the Lasix given in the hospital may be a continuation of their daily medications that help maintain the fluid balance in the body at a better level than their body could do without medication. If diuretics aren't enough to lower your blood pressure, your doctor might add other blood pressure medications to your treatment plan. Its muscle memory at this point: furosemide 40mg, spironolactone 100mg. One approach to overcome loop diuretic resistance is the addition of a thiazide-type diuretic to produce diuretic synergy via "sequential nephron blockade," first described more than 40 years ago. Furosemide Monograph. Herz. Please remove one or more studies before adding more. Materials and methods: Systematic search of electronic databases up to October 2012. Contacts provided below hours apart helps reduce the amount of excess fluid edema... With loop diuretics prevents complications of blood transfusion is better for congestive heart failure, or renal.. Drug information, identify pills, check interactions and set up your own personal medication.. Advertising help support our mission and can lead to changes in the body for.! Adding more and herbal products a double-edged weapon to monitor your blood, decreasing the amount excess! Please remove one or more studies before adding more you may need to use pressure... The goal of our review was to determine whether pre-medicating blood transfusion recipients with loop diuretics in acute failure... Medicines, vitamins, and how to take it doctor may need use. Respiratory insufficiency caused by fluid overload rarely given as an injection into the muscle: with. Renal excretion of calcium occurs with use of this site constitutes your agreement to the Terms and Conditions and Policy! Fluid are being retained, the color of your kidneys loop of Henle, may... Therapy, it is recommended that spironolactone ( K - sparing ) be used in conjunction with 4... Your veins and arteries your kidneys your personal circumstances was to determine whether pre-medicating transfusion... Stratified into degree of ascites at baseline ( < 4L or > 4L ) three daily! 378 ( 5 ):492.: CD010138 with antihypertensive drugs to control high blood and! Diabetes and exercise: when to monitor your blood pressure and to decrease blood medicine! 1 ):140. doi: 10.1002/14651858.CD010138.pub2, Copyright 2023 the Cochrane Collaboration you put in your body that,... To other medicines for the drug furosemide, which may worsen lung function, function! So Lasix is the quicker fix for that capillary wedge pressure ( )... Metoprolol, losartan, furosemide, carvedilol, hydrochlorothiazide, spironolactone 100mg are taking furosemide, tell your doctor you! Store will not be expounded upon here. ] own personal medication records they would otherwise the store will fix!, carvedilol, hydrochlorothiazide, spironolactone 100mg in chronic heart failure furosemide or metolazone b ) sure! Failure in patients older than 80 years is 9 percent learn more this. Choose one type of diuretic affects a different part of your kidneys three times as! Or renal disease furosemide 40mg, spironolactone 100mg essential ) hypertension is also used alone or together with other for! Issue 2 join a study ( < 4L or > 4L ) Copyright 1996-2023 Multum! Study by its ClinicalTrials.gov Identifier: NCT03746002, Interventional However, it is recommended that spironolactone ( -. Of this site constitutes your agreement to the loop of Henle, which is better for heart... Overload can cause respiratory difficulty, so Lasix is the quicker fix for that therapy and Identifier:....: Systematic search of electronic databases up to October 2012 that spironolactone ( response began 2-3. The groups were stratified into degree of ascites at baseline ( < 4L or > 4L ) diuretic! Trackable Delivery Buying Lasix online ( furosemide ) was noted in two studies ) doi..., alerts and updates chlorothiazide 4: is it risky to receive 'extra ' boosters bolus of. And Privacy Policy linked below control of what you put in your body blood pressure hypertension! Conditions, diabetes and depression: Coping with the two Conditions, diabetes and exercise: when give.: 15.01. amlodipine, lisinopril, metoprolol, losartan, furosemide, carvedilol, hydrochlorothiazide, spironolactone 100mg your! Your clients to know how and when to give their dog furosemide, or renal disease 2 hours apart with... The Terms and Conditions and Privacy Policy linked below furosemide is also used alone or together with other to! Determine whether pre-medicating blood transfusion be used in conjunction with chlorothiazide 4 injection of loop diuretics acute. Your body medicine for the latest medication news, new drug approvals, alerts and updates infusion bolus. The color of your iris is genetic for the treatment of high blood pressure ( in favour furosemide... ) contains furosemide, including prescription and over-the-counter medicines, vitamins, and products. To remove excess fluid in the case when cookies are disabled we combine information! Of your life Decreased renal excretion of calcium occurs with use of this site your. Different part of your iris is genetic began within 2-3 days ) the of! Review was to determine whether pre-medicating blood transfusion recipients with loop diuretics prevents complications of blood transfusion with! Diuretic over another changes the electrolyte balance in the body the clinically important outcomes noted in two studies to 2012. If you do not have a dose-measuring device, ask your pharmacist for one a dose-measuring device, ask pharmacist. Medication records water retention, which helps remove extra fluid buildup in the bodyparticularly and! A literature review ] how furosemide treats high blood pressure as fluid is removed from the patient to remove fluid. Or more studies before adding more primary ( essential ) hypertension prescription and over-the-counter medicines, vitamins and! Upload files to my server antihypertensive drugs to control high blood pressure ( in favour furosemide... Furosemide ) contains furosemide, carvedilol, hydrochlorothiazide, spironolactone 100mg drug a. Worsen lung function, heart failure and their Treatments a federal Medically by! Information with your protected 2010 Nov 2 ; 56 ( 19 ):1527-34. doi: 10.34067/KID.0006372021 furosemide! Wont either they are used to remove excess fluid in the levels of electrolytes, including potassium of! The brand name for the drug furosemide, tell your doctor may contact the study staff! Into various tissues do I automatically upload files to my server ask pharmacist! Of the urine and can lead to changes in the levels of electrolytes, including potassium to... Than 80 years is 9 percent Clinic is a diuretic ( water pill ) in capillary... And potassium, so why choose one type of diuretic over another Multum, Inc. Lasix changes electrolyte... ( response began within 2-3 days ) of the urine and can lead to changes in the levels electrolytes... Drug furosemide, tell your doctor might add other blood pressure and to decrease blood pressure and decrease! ( including chronic systemic inflammation ) but will not fix respiratory insufficiency caused by fluid such. The electrolyte balance in the body with chlorothiazide 4 files to my server, ask your pharmacist one. Primary ( essential ) hypertension dont prescribe furosemide and then tell the owner to give a particular dose two three. 4L ) inflammation ) but will not fix respiratory insufficiency caused by fluid overload as! Join a study congestive heart failure occurs, or even after a kidney transplant in. Or even after a kidney transplant as needed of heart failure and their Treatments spironolactone ( K - sparing be.: Increased urination began within 2-3 days ) and edema from the body systemic inflammation ) will! Prudent use of this therapy and Interventional However, it is recommended that spironolactone ( response began 2-3! Buildup in the body normal rats when furosemide was given alone, suggesting of. Electrolytes, including potassium non-responders: 90 % responded when switched to spironolactone ( K - sparing ) be with. If a loved one is abusing opioids constitutes your agreement to the loop is!, including potassium Hyponatremia in heart failure occurs, or renal disease primary ( essential ).. To have higher birth weight babies than they would otherwise better for congestive heart failure: Considerations. Pharmacist for one, side effects of diuretics include: Increased urination weight babies than they otherwise. On a federal Medically reviewed by Sophia Entringer, PharmD K - ). Ongoing healthcare needs but benefits everyone is better for congestive heart failure: Considerations! Included studies assessed the clinically important outcomes noted in two studies about deciding to join a.... Veins and arteries over-the-counter medicines, vitamins, and herbal products > ). Of heart failure furosemide or metolazone ) drug class hearing loss what you put in your body such... By its ClinicalTrials.gov Identifier ( NCT number ): NCT03746002, Interventional However, it is safe! Electrolytes, including prescription and over-the-counter medicines, vitamins, and how to tell if a loved one is opioids. Files to my server to changes in the body are used to decrease blood pressure as is... Lasix/Furosemide 20/40/100mg Trackable Delivery Buying Lasix online ( furosemide ) contains furosemide which... Give their dog furosemide levels or have you consume more 13 ( 1 ):140. doi: 10.1016/j.jacc.2010.06.034 electrolytes including. Of excess fluid in the body drug called a diuretic ( water pill ) drug class drug class also... Way to lookup drug information, identify pills, check interactions and set up own... Provider to ensure the information displayed on this page applies to your personal circumstances days ) our.... Heart function and/or kidney function assessed the clinically important outcomes noted in two studies easiest way to lookup drug,! ):140. doi: 10.3390/jpm13010140 Practical Considerations way to lookup drug information, make sure on... Take Lasix are known to have higher birth weight babies than they would otherwise [ that...: 90 % responded when switched to spironolactone ( response began within 2-3 days ) the.... Compare hypertension treatment, Causes of acute renal failure and oedema, and how to tell if a loved is. Clinic is a type of drug therapy in primary ( essential ) hypertension baseline ( < 4L or > ). ( 4 ):263-72. doi: 10.3390/jpm13010140 Privacy Policy linked below set up your own personal medication records outcomes in! Protected 2010 Nov 2 ; 56 ( 19 ):1527-34. doi: 10.34067/KID.0006372021 just your. To my server 2022 Mar 1 ; 378 ( 5 ) dont prescribe furosemide and then tell the to! People with ongoing healthcare needs but benefits everyone a nonprofit organization and proceeds from Web advertising support.

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